Scientist I/II, LNP Formulations

Role details

Scientist I/II, LNP Formulations

Cambridge, MA

Monday-Friday 9am-5pm

Seeking a Scientist I/II specializing in Lipid Nanoparticle (LNP) Formulations to lead the design, execution, and analysis of experiments for next-generation LNP systems. This role focuses on developing, optimizing, and characterizing LNPs for nucleic acid delivery in a dynamic research setting.

Responsibilities

• Design and analyze experiments using DOE approaches to create and optimize innovative LNP formulations.
• Drive formulation innovation by selecting lipids, optimizing compositions, and evaluating process parameters.
• Conduct LNP screening and characterization, assessing size, PDI, encapsulation efficiency, stability, and performance.
• Utilize analytical and statistical methods to interpret complex data and inform formulation strategies.
• Collaborate with multidisciplinary teams to advance research and development programs.
• Document experiments thoroughly and communicate findings and recommendations to stakeholders.
• Troubleshoot formulation issues and enhance experimental workflows for continuous improvement.
• Support scale-up processes and technology transfer activities as required.

Qualifications

• PhD or MS in Chemistry, Pharmaceutical Sciences, Chemical Engineering, Materials Science, or a related discipline.
• Hands-on experience with LNP formulation development and optimization.
• Expertise in DOE methodologies and statistical experimental design.
• Proficiency in LNP screening and analytical techniques such as DLS, encapsulation assays, stability studies, and physicochemical characterization.
• Strong understanding of lipid-based delivery systems and formulation science.
• Demonstrated ability to work effectively in a fast-paced, team-oriented environment.
• Excellent problem-solving skills and capability to manage multiple priorities.
• Effective communication skills for presenting data and influencing technical decisions.